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City of Hope, an innovative biomedical research, treatment and educational institution, is dedicated to the prevention and cure of cancer and other life-threatening diseases, guided by a compassionate, patient-centered philosophy and supported by a national foundation of humanitarian philanthropy. City of Hope is dedicated to making a difference in the lives of people with cancer, diabetes and other serious illnesses. Our mission is to transform the future of health care by turning science into a practical benefit, hope into reality. We accomplish this by providing outstanding care, conducting innovative research and offering vital education programs focused on eliminating these diseases. Founded in 1913, City of Hope is one of only 41 comprehensive cancer centers in the nation, as designated by the National Cancer Institute. Our role as leaders in patient care, basic and clinical research, and the translation of science into tangible benefit is widely acknowledged. Our community includes research associates, scientists, doctors, nurses, allied health professionals, graduate students, fundraising specialists, marketing professionals, volunteers and an extensive support staff. We are united by our desire to find cures, save lives and transform the future of health. Every discovery we make and every new treatment we create gives people the chance to live longer, better and more fully. City of Hope continues to be a pioneer of patient centered care and remains committed to its tradition of exceptional care for patients, families and communities. Each day, we live out our credo: "There is no profit in curing the body, if, in the process, we destroy the soul."

The National Multiple Sclerosis Society's mission is to cure multiple sclerosis while empowering people affected by multiple sclerosis (MS) to live their best lives. The organization pledges to accelerate cures through global leadership, and improve access to personalized, affordable, high-quality MS healthcare. It empowers people affected by MS to solve everyday challenges and strengthens the MS movement through more and deeper connections.

Direct Relief improves the health and lives of people affected by poverty or emergency situations by mobilizing and providing essential medical resources needed for their care. Direct Relief works in all 50 U.S. states and in more than 90 countries to expand access to medicine and healthcare by equipping doctors and nurses with lifesaving medical resources.

The American Foundation for Suicide Prevention is dedicated to saving lives and bringing hope to those affected by suicide. AFSP creates a culture that’s smart about mental health through education and community programs, develops suicide prevention through research and advocacy, and provides support for those affected by suicide. AFSP has local chapters in all 50 states with programs and events nationwide.

The Parkinson’s Foundation makes life better for people with Parkinson’s disease by improving care and advancing research toward a cure. In everything we do, we build on the energy, experience and passion of our global Parkinson’s community.

Established in 1985, The ALS Association is dedicated to leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support. The Association builds hope and enhances the quality of life while aggressively searching for new treatments and a cure, through global research, providing assistance for people with ALS through a nationwide network of chapters, coordinating multidisciplinary care through certified clinical care centers, and fostering government partnerships.

Nancy G. Brinker promised her sister that she would do everything in her power to end breast cancer forever. That promise is now Susan G. Komen for the Cure®, the global leader of the breast cancer movement, having invested more than $2.2 billion since inception in 1982. As the world’s largest grassroots network of breast cancer survivors and activists, we’re working together to save lives, empower people, ensure quality care for all and energize science to find the cures. Thanks to events like the Susan G. Komen Race for the Cure® and the Susan G. Komen 3-Day for the Cure®, and generous contributions from our partners, sponsors and fellow supporters, we have become the largest source of nonprofit funds dedicated to the fight against breast cancer in the world.

RAINN (Rape, Abuse & Incest National Network) is the nation's largest anti-sexual violence organization and was named one of "America's 100 Best Charities" by Worth magazine. RAINN created and operates the National Sexual Assault Hotline (800.656.HOPE and online.rainn.org) in partnership with more than 1,100 local rape crisis centers across the country and operates the DoD Safe Helpline for the Department of Defense. RAINN also carries out programs to prevent sexual violence, help victims and ensure that rapists are brought to justice.

The Trevor Project is the world’s largest suicide prevention and crisis intervention organization for LGBTQ+ (lesbian, gay, bisexual, transgender, queer, and questioning) young people. The organization works to save young lives by providing support through free and confidential suicide prevention and crisis intervention programs on platforms where young people spend their time: a 24/7 phone lifeline, chat, and text. The organization also runs TrevorSpace, the world’s largest safe space social networking site for LGBTQ youth, and operates innovative education, research, and advocacy programs.

CARE is a leading humanitarian organization fighting global poverty. We place special focus on working alongside poor women because, equipped with the proper resources, women have the power to help whole families and entire communities escape poverty. Women are at the heart of CARE's community-based efforts to improve basic education, prevent the spread of HIV, increase access to clean water and sanitation, expand economic opportunity and protect natural resources. CARE also delivers emergency aid to survivors of war and natural disasters, and helps people rebuild their lives.

The International Rescue Committee responds to the world's worst humanitarian crises, helping to restore health, safety, education, economic wellbeing, and power to people devastated by conflict and disaster. Founded in 1933 at the call of Albert Einstein, the IRC is at work in over 50 countries and more than 20 U.S. cities helping people to survive, reclaim control of their future and strengthen their communities. Over the past 90 years, the IRC has built a strong position as the largest refugee resettlement agency in the United States, and has paid close attention and provided service to the recent conflicts in Afghanistan (providing education and protection to 1 million Afghan citizens including women and girls) and Ukraine (collaborating with nonprofit organizations in both Ukraine and refugee-receiving Poland to provide aid).

UNICEF's mission is to help very child thrive, all over the world. Over eight decades, it has built an unprecedented global support system for the world’s children. UNICEF relentlessly works day in and day out to deliver the essentials that give every child an equitable chance in life: health care and immunizations, safe water and sanitation, nutrition, education, emergency relief and more. UNICEF USA advances the global mission of UNICEF by rallying the American public to support the world’s most vulnerable children. Through advocacy, education and fundraising in the United States. The organization's Impact Fund for Children provides opportunities for social impact investors seeking to make a difference in the survival and development of children.